find informations from telephone number (location, Carrier, type, etc)
http://decoder.americom.com/
http://www.primeris.com/fonefind/
2003年12月23日
tutorial: create mac aqua style icons using photoshop:
http://www.macmerc.com/sections.php?op=viewarticle&artid=70
manually:
http://mac.xicons.com/help/bice/aquatutorial.php
http://www.xanthic.net/tutorials/pstut_aquasphere.html
2003年12月6日
2003年12月3日
maybe I can combine "Self-Organizing Map" and my "drug auto refiner" and "cocktail treatment"
2003年11月20日
for protein modeling, now there's some automatic modeling site.
PredictProtein (combind several methods) (1 day)
3D-pssm (Fold Recognition ) (10~20 min)
SWISS-MODEL (Homology modeling) (fastest, 1min)
2003年11月16日
2003年11月13日
to use sybyl do 3d qsar on nci data:
put compounds in database,
change compounds' name to something doesn't content special char.
use "align database" to align compounds,
leave a core structure in molecular area will help you do the align.
search nci data and display in mdl mol format, then the core structure info can be get from the html source code, writing in MDL script.
you can use this command to get mol files.
wget -r --accept=mol http://129.43.27.140/tmp/hitscmUaRJ.html
you can use link like this to get GI50 data of NSC94600
http://129.43.27.140/cgi-bin/nci2.tcl/nci_download94600.tab?output=E_GI50&tablefmt=tabtable&op1=nsc&data1=94600&nomsg=0
or
http://cactus.nci.nih.gov/cgi-bin/nci2.tcl?op1=nsc&data1=94600&output=detail&conflist=-1&passid=&nomsg=1
sybyl servers in umdnj
achilles.umdnj.edu are pretty fast due to users usually use apollo and titan.
MDL mol file format works fine on NCI, so I planed to download MDL mol file then convert to sybyl mol2 file format. (maybe use openbabel)
tested by using babel to convert it. it works this way.
I don't know why files generated by nci can't be read by sybyl, ex: pdb not work, sybyl mol2 not work. mol not work, should be convert by using babel.
when babel don't work, put the files in a dos8 directory, ex: use d:\temp instead of d:\program files\...
now, the only thing left is, how can I align those compounds by the core substructure automatically.
2003年11月11日
It's a long time I didn't touch MAYA (a 3D modeling software for Computer Graphic)
now it has amazing features.
here are online tutorials via Streaming Videos
2003年11月8日
about MSN messenger:
Java MSN real status viewer (I can't get it work)
Triople can detect if a msn user is online of not. (web interface)
and you can even send message to an user who already blocked you by changing your nick name to a magic string.
(a special software to change nick name is required)
this "Online Status Indicator server" can let users know if someone is online or not.
but can't detect real status.
2003年11月3日
3D Minder cluster the anti-cancer compounds for you (need specific browser and java version +java3d)
Self-Organized Map cluster the anti-hiv compounds for you.
2003年11月2日
this paper use JKlustor to cluster Anti-HIV compounds in NCI database.
Weka
tutorial about how to select variables
Weka can easily use CSV files.
2003年10月30日
2003年10月29日
3D Mind will cluster your compounds for you.
and it can also show you what else are in that cluster.
go into 3D Mind tools and use node 23+18 (cluster 16.8 + 17.9)
or node 13+11+7+3+...
or you can search by SMILE string: "C1CC3=C(CO1)CN2CC5=C(C2=C3)N=C4C=CC=CC4=C5" here
here's a paper uses NCI's anticancer database to do QSAR
found a pretty good entry to find cancer screen data from nci
for aids screen data get compouds here then get activity here or see structures here
what is GI50 TGI LC50 in nci database
you can use online tools: NCI 3DMiner or Enhanced NCI Database Browser to search compounds list here, then you can easily compare those compounds.
after you saw some substructure shared by all the structures above,
and got more structures by substructure search.
you can use this page to see there activies.
Ward in JKlustor can work with GenerateMD then you can Clustering using Pharmacophore Fingerprints.
Ref: example section of this page
2003年10月28日
you can use Jarp and Ward in JKlustor
to cluster the compounds based on NCI's data
ref: http://www.chemaxon.com/conf/Eurocombi_poster_Ltr.pdf
there's a freeware like ghost
called g4u (ghost for unix)
works in a floppy disk and can upload harddisk image to a ftp server. and dump to another computer's harddisk.
I think I can find a drug for AIDS here.(example)
and it will gives me several similar compounds and CAS#
then I can use those CAS# to search activity data here
for Cancer, use these Drugs list1 Drug List 2 and Acitivity
PS: if interested in anti-cancer plants, you can find it and compounts it produced here or here.
2003年10月26日
Oops, I WAS planing to do an automated QSAR program for binf7592
but after I read Ch.5.3.3 in the paper "Structure Database" teacher gave us on 10/20.
I noticed there are several tools exist. "Catalyst" and "APEX"
details about catalyst and apex
we know SMILES is not Unique.
but it's very easy to Translate to unique smiles.
2003年10月23日
use meme to find motifs
./meme ../../markfilter/shrtincor.fa -protein -mod zoops -nmotifs 20 -minsites 2 -maxsites 5 -minw 3 -maxw 50 -evt 10000 -time 7200 -maxsize 60000 -nostatus -maxiter 25 > output.html
use meta-meme to make hmm
./mhmm -meme ../../../meme.3.0.4/bin/output.html > test.mhmm
test sequences using that hmm
./mhmmscan -hmm test.mhmm -seq ../../../markfilter/shrtcor.fa 2>/dev/null | more
2003年10月22日
using netcat to scan your computer ports:
nc -v -z 192.168.1.102 1-9999
will scan port 1~port 9999 for you without delay.
2003年10月17日
at the end of following page, you'll see how to use SAS to analyze multiple variables.
http://www.stat.ncsu.edu/~st512_info/dickey/crsnotes/rnotes_unbal.htm
ex: I know HFE7 associat with HAC1E, but will it be different between man and woman(HSSEX)?
After 4 days trying, I finally know how to use SAS to figure out which variable is associate with specific variable.
you can use following SAS program to figure out which variable between HAC1A~HAC1O
are associate with HFE7;
--------------------------
proc glm data=adult;
class HAC1A HAC1B HAC1D HAC1E HAC1F HAC1G HAC1H HAC1I HAC1J HAC1K HAC1L HAC1M HAC1N HAC1O;
model HAC1A HAC1B HAC1D HAC1E HAC1F HAC1G HAC1H HAC1I HAC1J HAC1K HAC1L HAC1M HAC1N HAC1O=HFE7;
run;
--------------------------
after you find something's P<0.05 (ex:HAC1E)
you can use following SAS program to see
what's the different between group 1 and 2 in HFE7
--------------------------
proc glm data=adult;
class HFE7;
model HAC1E=HFE7;
lsmeans HFE7;
run;
--------------------------
binf7540
this helps
http://www.ats.ucla.edu/stat/sas/faq/contrast.htm
2003年10月15日
For scan your network holes:
Leak Testers:
LeakTest - http://grc.com/lt/leaktest.htm
TooLeaky - http://tooleaky.zensoft.com
Firehole - http://keir.net/firehole.html
Yalta - http://www.soft4ever.com/security_test/En/index.htm
Online Port Scanners:
Sygate – Option in software menu.
Symantec - http://www.symantec.com/cgi-bin/securitycheck.cgi
PC Flank - http://www.pcflank.com/index.htm
2003年10月13日
2003年10月12日
I previously misunderstood this site (http://www.fruitfly.org/seq_tools/splice.html)
it shows the donor site's start point and end point but not the cut position.
after this understanding, it can be used in binf7600's project.
I think I can find Alternative Splicing Sequences and data from ProSplicer,
to prove my model,
then train my model.
today NetGene2 not work, so I try to find others.
http://l25.itba.mi.cnr.it/~webgene/wwwgene.html
http://bioinformatics.iastate.edu/cgi-bin/sp.cgi
maybe try if "exonic splicing enhancers predictor" can help improve ours or not.
ref: http://nar.oupjournals.org/cgi/reprint/31/13/3568.pdf
this site do the same thing as me, connect to other sites to obtain interstat values.
ref: http://www.inra.fr/bia/T/schiex/Export/LNCS-EuGene.pdf
this software is a A Generic Framework for the Integration of Gene-Prediction Data
ref: http://www.genome.org/cgi/reprint/12/9/1418.pdf
2003年10月11日
figure 4 in this paper proved my third theory(10/8/03).
I found a scary thing in my special Linux cd,
although I know that CD is a very powerful cd,
I don't know it's that scary...
it not only has ethereal, tcpdump,
it also has "ettercap"!
a tool which can hack even in switch env, ssh, OS fingerprint, disconnect connections, type charactors for others!
here's a very very good introduction of this kind of tech and tools. and ways to prevent!
2003年10月10日
I got a material totally support my theory(10/8/03), and they also got an interesting paper talking about differences in RNA splicing between normal cell and aged cell.
I think this group are going the same direction as me.
You can use Blogger API to extract your blog from blogger.com in XML format
tested using WSDL and SoapClient web interface
2003年10月8日
I found part of the answer why hnRNP needed in RNA splicing (to cut intro exon).
Because hnRNP A2 on RNA will use kinesin on microtubule to move it self. (supported by this paper)
and this paper also support my theory
so it can move two splicesome together (my theory).
this paper support my another theory, "a novel class of genes which, although they encode polyadenylated RNA, might not make a translated protein."
this abstract also support my third theory, when enzyme see the sequence, they don't know if they cut the right place or not, they just cut it. There's other place to check if they cut right or not.
and I'll use these three theory in my binf7600 project.
and this one should be able to help me to detect hnRNP binding site.
(I found this on 10/10/03, which draw exactly as I thought! and support all my theory!)
you can search similar structures or substructures using
http://cactus.nci.nih.gov/ncidb2/
and AIDS, Cancer activity also. (not working on 10/8/03)
Since I can't use SAS to do analyze at PC Lab, due to Go Back and hard disk limit in PC Lab, I decide to do it at home.
Since I don't have SAS and it cost $50 for student version and only work for 3 months, I decide to use something free.
So I found OpenStat, a freeware which can do lots of statistics analysis.
It has both windows and Linux version.
Now I use SAS at school to translate data to CVS format, but I think I should write a translator to do that for rapidly use.
2003年10月7日
2003年10月6日
Tested
ISIS Draw
and
ChemSketch
for binf7592
I like ChemSketch, cause it can check the structure for me easily, both in 2D and 3D.
but if I need to create something like Markush Structure, I think I'll use ChemSketch first then use ISIS Draw to make it like Markush Structure.
after one day testing and researching,
I found the answer of my problems,
VMWare's NIC doesn't support PXE.
ClusterKnoppix 9/5/03 version has "terminalserver + etherboot" bug
should be fixed in 9/24/03 version
bochs a virtual pc software like vmware but it's opensource.
2003年10月5日
What is Markush Structure? (Chinese)
How to search pharmaceutical compounds in patent database using Markush Structure search.
more info
2003年10月3日
How to make an NCBI Blast at home on clusters with OpenMosix support?
http://stl.bioinformatics.med.umich.edu/software/OM_BLAST_patch/openmosixpatch.html
2003年10月1日
today, I saw something that I want to create in the past.
a cluster system which requires no installation, no harddisk.
only a cdrom pop into PCs, then it works as one clustered system.
so it can easily work in pc labs in school. :p
It called clusterknoppix
and it's better!
client nodes doesn't even need CDROM! (when boot from PXE chips [rom])
or a floppy disk
2003年9月28日
I was thinking about a tool can save my informations in nested tree structure.
I think this is the answer.
http://www.basil28.com/tree/xmltree.htm
which use xml and flash to do it. and can easily add, delete, nodes with title, link. and can change style easily.
and can save and open xml files.
2003年9月27日
I'm trying to test exon intron prediction software,
when tested in GeneMark, I got a bad result.
then I found NetGene2 on google.
and have a very good result, and useful information (ex:calculations).
and also has paper discribing it's algorithm.
maybe I can get values from NetGene2 and do some improvement.
================
they also has tool, GenePublisher, to let you input microarray data, and get microarray analysis report. Just like what I did for my uncle.
================
in BINF5230, Fall 2002, we've use Grail to predict exon & intron.
now, it has Grail-1.3
in "Grail 2 Exons", you can check "Clusters", and you'll have almost all the possible position where correct exon intron will be.
maybe I can get all the possible position from Grail and then check each point using my own algorithm.
2003年9月24日
2003年9月21日
如何知道microsoft & yahoo等大公司內部資料
如: 他們的server可能架構, 他們的程式可能的演算法
ex:查詢IBM有哪些專利
免費查詢美國專利
http://www.uspto.gov/patft/
2003年9月16日
2003年9月4日
Q:use script to do telnet stuff
A:two ways,
1.Use "expect" command example
2.Use perl's Net::Telnet example additional info
2003年9月3日
用Javascript做TreeView做得最好的網站
Treeview JavaScript tree menu
包括nested checkbox, use as form, tree from database...